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dc.contributor.authorAndrews, Cen
dc.contributor.authorNettle, Den
dc.contributor.authorLarriva, Men
dc.contributor.authorGillespie, Ren
dc.contributor.authorReichert, Sen
dc.contributor.authorBrilot, BOen
dc.contributor.authorBedford, Ten
dc.contributor.authorMonaghan, Pen
dc.contributor.authorSpencer, KAen
dc.contributor.authorBateson, Men
dc.date.accessioned2017-11-01T11:42:14Z
dc.date.available2017-11-01T11:42:14Z
dc.date.issued2017-09en
dc.identifier.issn2054-5703en
dc.identifier.urihttp://hdl.handle.net/10026.1/10125
dc.description.abstract

The acute stress response functions to prioritize behavioural and physiological processes that maximize survival in the face of immediate threat. There is variation between individuals in the strength of the adult stress response that is of interest in both evolutionary biology and medicine. Age is an established source of this variation-stress responsiveness diminishes with increasing age in a range of species-but unexplained variation remains. Since individuals of the same chronological age may differ markedly in their pace of biological ageing, we asked whether biological age-measured here via erythrocyte telomere length-predicts variation in stress responsiveness in adult animals of the same chronological age. We studied two cohorts of European starlings in which we had previously manipulated the rate of biological ageing by experimentally altering the competition experienced by chicks in the fortnight following hatching. We predicted that individuals with greater developmental telomere attrition, and hence greater biological age, would show an attenuated corticosterone (CORT) response to an acute stressor when tested as adults. In both cohorts, we found that birds with greater developmental telomere attrition had lower peak CORT levels and a more negative change in CORT levels between 15 and 30 min following stress exposure. Our results, therefore, provide strong evidence that a measure of biological age explains individual variation in stress responsiveness: birds that were biologically older were less stress responsive. Our results provide a novel explanation for the phenomenon of developmental programming of the stress response: observed changes in stress physiology as a result of exposure to early-life adversity may reflect changes in ageing.

en
dc.format.extent171208 - ?en
dc.languageengen
dc.language.isoengen
dc.subjectSturnus vulgarisen
dc.subjectbiological ageen
dc.subjectcorticosteroneen
dc.subjectearly-life adversityen
dc.subjectstress responseen
dc.subjecttelomereen
dc.titleA marker of biological age explains individual variation in the strength of the adult stress response.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/28989794en
plymouth.issue9en
plymouth.volume4en
plymouth.publication-statusPublished onlineen
plymouth.journalR Soc Open Scien
dc.identifier.doi10.1098/rsos.171208en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/00 Groups by role
plymouth.organisational-group/Plymouth/00 Groups by role/Academics
plymouth.organisational-group/Plymouth/Faculty of Health and Human Sciences
plymouth.organisational-group/Plymouth/Faculty of Health and Human Sciences/School of Psychology
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering/School of Biological and Marine Sciences
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA04 Psychology, Psychiatry and Neuroscience
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Centre for Brain, Cognition and Behaviour (CBCB)
dc.publisher.placeEnglanden
dcterms.dateAccepted2017-08-31en
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1098/rsos.171208en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-09en
rioxxterms.typeJournal Article/Reviewen


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