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dc.contributor.authorLynch, TR
dc.contributor.authorWhalley, B
dc.contributor.authorHempel, RJ
dc.contributor.authorByford, S
dc.contributor.authorClarke, P
dc.contributor.authorClarke, S
dc.contributor.authorKingdon, D
dc.contributor.authorO'Mahen, H
dc.contributor.authorRussell, IT
dc.contributor.authorShearer, J
dc.contributor.authorStanton, M
dc.contributor.authorSwales, M
dc.contributor.authorWatkins, A
dc.contributor.authorRemington, B
dc.date.accessioned2017-10-13T13:27:59Z
dc.date.available2017-10-13T13:27:59Z
dc.date.issued2015-07
dc.identifier.issn2044-6055
dc.identifier.issn2044-6055
dc.identifier.otherARTN e008857
dc.identifier.urihttp://hdl.handle.net/10026.1/10059
dc.description.abstract

<jats:sec><jats:title>Introduction</jats:title><jats:p>Only 30–40% of depressed patients treated with medication achieve full remission. Studies that change medication or augment it by psychotherapy achieve only limited benefits, in part because current treatments are not designed for chronic and complex patients. Previous trials have excluded high-risk patients and those with comorbid personality disorder. Radically Open Dialectical Behaviour Therapy (RO-DBT) is a novel, transdiagnostic treatment for disorders of emotional over-control. The REFRAMED trial aims to evaluate the effectiveness and cost-effectiveness of RO-DBT for patients with treatment-resistant depression.</jats:p></jats:sec><jats:sec><jats:title>Methods and analysis</jats:title><jats:p>REFRAMED is a multicentre randomised controlled trial, comparing 7 months of individual and group RO-DBT treatment with treatment as usual (TAU). Our primary outcome measure is depressive symptoms 12 months after randomisation. We shall estimate the cost-effectiveness of RO-DBT by cost per quality-adjusted life year. Causal analyses will explore the mechanisms by which RO-DBT is effective.</jats:p></jats:sec><jats:sec><jats:title>Ethics and dissemination</jats:title><jats:p>The National Research Ethics Service (NRES) Committee South Central – Southampton A first granted ethical approval on 20 June 2011, reference number 11/SC/0146.</jats:p></jats:sec><jats:sec><jats:title>Trial registration number</jats:title><jats:p>ISRCTN85784627.</jats:p></jats:sec>

dc.format.extente008857-e008857
dc.format.mediumElectronic
dc.languageen
dc.language.isoeng
dc.publisherBMJ
dc.subjectRadically Open Dialectical Behaviour Therapy
dc.subjectRefractory Depression
dc.subjectStudy Protocol
dc.subjectBehavior Therapy
dc.subjectCost-Benefit Analysis
dc.subjectDepression
dc.subjectDrug Resistance
dc.subjectHumans
dc.subjectQuality-Adjusted Life Years
dc.subjectResearch Design
dc.subjectRetreatment
dc.titleRefractory depression: mechanisms and evaluation of radically open dialectical behaviour therapy (RO-DBT) [REFRAMED]: protocol for randomised trial
dc.typejournal-article
dc.typeArticle
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/26187121
plymouth.issue7
plymouth.volume5
plymouth.publisher-urlhttp://dx.doi.org/10.1136/bmjopen-2015-008857
plymouth.publication-statusPublished
plymouth.journalBMJ Open
dc.identifier.doi10.1136/bmjopen-2015-008857
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/School of Psychology
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA04 Psychology, Psychiatry and Neuroscience
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Centre for Brain, Cognition and Behaviour (CBCB)
plymouth.organisational-group/Plymouth/Research Groups/Centre for Brain, Cognition and Behaviour (CBCB)/Behaviour
plymouth.organisational-group/Plymouth/Research Groups/Plymouth Institute of Health and Care Research (PIHR)
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeEngland
dcterms.dateAccepted2015-06-30
dc.identifier.eissn2044-6055
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1136/bmjopen-2015-008857
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review


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