Now showing items 1-2 of 2
The neurotoxic effects of Manganese and the novel protective role of Drp1 in the autophagy pathway
(University of Plymouth, 2020)
The precise pathological mechanism of Manganese (Mn) is not yet known however prior evidence suggests a prominent role of mitochondrial dysfunction. Relevant to Parkinson’s disease, Mn is known to bind to α-synuclein and ...
The role of DAXX in the selective autophagy receptor SQSTM1/p62 phase condensation
(University of Plymouth, 2021)
Macroautophagy (‘autophagy’ hereafter) is a lysosome-dependent degradation system for intracellular protein quality control. Autophagy can selectively remove cargo materials, which is dependent on cargo receptors. SQSTM1/p62 ...