Now showing items 1-5 of 5

  • Gene expression analysis in human breast cancer associated blood vessels. 

    Jones, DT; Lechertier, T; Mitter, R; Herbert, JMJ; Bicknell, R; Jones, JL; Li, J-L; Buffa, F; Harris, AL; Hodivala-Dilke, K (United States, 2012)
    Angiogenesis is essential for solid tumour growth, whilst the molecular profiles of tumour blood vessels have been reported to be different between cancer types. Although presently available anti-angiogenic strategies are ...
  • A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes. 

    Hill, R; Kalathur, RKR; Callejas, S; Colaço, L; Brandão, R; Serelde, B; Cebriá, A; Blanco-Aparicio, C; Pastor, J; Futschik, M; Dopazo, A; Link, W (England, 2014-12-09)
    INTRODUCTION: The activation of the phosphoinositide 3-kinase (PI3K)/AKT signalling pathway is one the most frequent genetic events in breast cancer, consequently the development of PI3K inhibitors has attracted much ...
  • Physical and functional interaction between the Bloom's syndrome gene product and the largest subunit of chromatin assembly factor 1. 

    Jiao, R; Bachrati, CZ; Pedrazzi, G; Kuster, P; Petkovic, M; Li, J-L; Egli, D; Hickson, ID; Stagljar, I (United States, 2004-06)
    Bloom's syndrome (BS) is a genomic instability disorder characterized by cancer susceptibility. The protein defective in BS, BLM, belongs to the RecQ family of DNA helicases. In this study, we found that BLM interacts ...
  • Regulation of radial glial survival by signals from the meninges. 

    Radakovits, R; Barros, CS; Belvindrah, R; Patton, B; Müller, U (United States, 2009-06-17)
    Radial glial cells (RGCs) in the developing cerebral cortex are progenitors for neurons and glia, and their processes serve as guideposts for migrating neurons. So far, it has remained unclear whether RGC processes also ...
  • Towards an alternative testing strategy for nanomaterials used in nanomedicine: lessons from NanoTEST. 

    Dusinska, M; Boland, S; Saunders, M; Juillerat-Jeanneret, L; Tran, L; Pojana, G; Marcomini, A; Volkovova, K; Tulinska, J; Knudsen, LE; Gombau, L; Whelan, M; Collins, AR; Marano, F; Housiadas, C; Bilanicova, D; Halamoda Kenzaoui, B; Correia Carreira, S; Magdolenova, Z; Fjellsbø, LM; Huk, A; Handy, R; Walker, L; Barancokova, M; Bartonova, A; Burello, E; Castell, J; Cowie, H; Drlickova, M; Guadagnini, R; Harris, G; Harju, M; Heimstad, ES; Hurbankova, M; Kazimirova, A; Kovacikova, Z; Kuricova, M; Liskova, A; Milcamps, A; Neubauerova, E; Palosaari, T; Papazafiri, P; Pilou, M; Poulsen, MS; Ross, B; Runden-Pran, E; Sebekova, K; Staruchova, M; Vallotto, D; Worth, A (England, 2015-05)
    In spite of recent advances in describing the health outcomes of exposure to nanoparticles (NPs), it still remains unclear how exactly NPs interact with their cellular targets. Size, surface, mass, geometry, and composition ...

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