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  • IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide. 

    Ramcharan, R; Aleksic, T; Kamdoum, WP; Gao, S; Pfister, SX; Tanner, J; Bridges, E; Asher, R; Watson, AJ; Margison, GP; Woodcock, M; Repapi, E; Li, J-L; Middleton, MR; Macaulay, VM (United States, 2015-11-24)
    Prior studies implicate type 1 IGF receptor (IGF-1R) in mediating chemo-resistance. Here, we investigated whether IGF-1R influences response to temozolomide (TMZ), which generates DNA adducts that are removed by ...

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