Browsing by Subject "B-Lymphocytes"
Now showing items 1-4 of 4
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Complete analysis of the B-cell response to a protein antigen, from in vivo germinal centre formation to 3-D modelling of affinity maturation.
(England, 2003-03)Somatic hypermutation of immunoglobulin variable region genes occurs within germinal centres (GCs) and is the process responsible for affinity maturation of antibodies during an immune response. Previous studies have ... -
Neutralizing antibodies and pathogenesis of hepatitis C virus infection.
(Switzerland, 2012-10-09)Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide. The interplay between the virus and host innate and adaptive immune responses determines the outcome of infection. There is increasing ... -
NFATc1 affects mouse splenic B cell function by controlling the calcineurin--NFAT signaling network.
(United States, 2011-04-11)By studying mice in which the Nfatc1 gene was inactivated in bone marrow, spleen, or germinal center B cells, we show that NFATc1 supports the proliferation and suppresses the activation-induced cell death of splenic B ... -
A novel Cre recombinase imaging system for tracking lymphotropic virus infection in vivo.
(United States, 2009-08-04)BACKGROUND: Detection, isolation, and identification of individual virus infected cells during long term infection are critical to advance our understanding of mechanisms of pathogenesis for latent/persistent viruses. ...