Now showing items 1-4 of 4

  • Complete analysis of the B-cell response to a protein antigen, from in vivo germinal centre formation to 3-D modelling of affinity maturation. 

    Adams, CL; Macleod, MKL; James Milner-White, E; Aitken, R; Garside, P; Stott, DI (England, 2003-03)
    Somatic hypermutation of immunoglobulin variable region genes occurs within germinal centres (GCs) and is the process responsible for affinity maturation of antibodies during an immune response. Previous studies have ...
  • Neutralizing antibodies and pathogenesis of hepatitis C virus infection. 

    Fafi-Kremer, S; Fauvelle, C; Felmlee, DJ; Zeisel, MB; Lepiller, Q; Fofana, I; Heydmann, L; Stoll-Keller, F; Baumert, TF (Switzerland, 2012-10-09)
    Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide. The interplay between the virus and host innate and adaptive immune responses determines the outcome of infection. There is increasing ...
  • NFATc1 affects mouse splenic B cell function by controlling the calcineurin--NFAT signaling network. 

    Bhattacharyya, S; Deb, J; Patra, AK; Thuy Pham, DA; Chen, W; Vaeth, M; Berberich-Siebelt, F; Klein-Hessling, S; Lamperti, ED; Reifenberg, K; Jellusova, J; Schweizer, A; Nitschke, L; Leich, E; Rosenwald, A; Brunner, C; Engelmann, S; Bommhardt, U; Avots, A; Müller, MR; Kondo, E; Serfling, E (United States, 2011-04-11)
    By studying mice in which the Nfatc1 gene was inactivated in bone marrow, spleen, or germinal center B cells, we show that NFATc1 supports the proliferation and suppresses the activation-induced cell death of splenic B ...
  • A novel Cre recombinase imaging system for tracking lymphotropic virus infection in vivo. 

    Dutia, BM; Reid, SJ; Drummond, DD; Ligertwood, Y; Bennet, I; Rietberg, W; Silvia, O; Jarvis, MA; Nash, AA (United States, 2009-08-04)
    BACKGROUND: Detection, isolation, and identification of individual virus infected cells during long term infection are critical to advance our understanding of mechanisms of pathogenesis for latent/persistent viruses. ...

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