Browsing by Author "34122bbd-9797-49d5-a876-17bb2aa6d7c3"
Now showing items 1-20 of 22
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Adverse Outcome Pathways can drive non-animal approaches for safety assessment.
(England, 2015-09)Adverse Outcome Pathways (AOPs) provide an opportunity to develop new and more accurate safety assessment processes for drugs and other chemicals, and may ultimately play an important role in regulatory decision making. ... -
Assessing the exposure risk and impacts of pharmaceuticals in the environment on individuals and ecosystems.
(England, 2013-08-23)The use of human and veterinary pharmaceuticals is increasing. Over the past decade, there has been a proliferation of research into potential environmental impacts of pharmaceuticals in the environment. A Royal ... -
Developmental toxicity of metaldehyde in the embryos of Lymnaea stagnalis (Gastropoda: Pulmonata) co-exposed to the synergist piperonyl butoxide.
(Netherlands, 2016-02-01)Metaldehyde is a widely used molluscicide in countries where damage to crops from slugs and snails is a major problem associated with warm and wet winters. In the UK it is estimated that over 8% of the area covered by ... -
Ecological risk assessment of endocrine disruptors.
(United States, 2000-11)The European Centre for Ecotoxicology and Toxicology of Chemicals proposes a tiered approach for the ecological risk assessment of endocrine disruptors, integrating exposure and hazard (effects) characterization. Exposure ... -
Effects of ammonium perchlorate on thyroid function in developing fathead minnows, Pimephales promelas.
(United States, 2005-04)Perchlorate is a known environmental contaminant, largely due to widespread military use as a propellant. Perchlorate acts pharmacologically as a competitive inhibitor of thyroidal iodide uptake in mammals, but the impacts ... -
Expression of target and reference genes in Daphnia magna exposed to ibuprofen.
(Springer Nature, 2006) -
The future trajectory of adverse outcome pathways: a commentary
(Springer Verlag, 2018-04) -
Impacts of the mycotoxin zearalenone on growth and photosynthetic responses in laboratory populations of freshwater macrophytes (Lemna minor) and microalgae (Pseudokirchneriella subcapitata).
(Elsevier, 2019-03)Mycotoxins are an important class of chemicals of emerging concern, recently detected in aquatic environments, potentially reflecting the influence of fungicide resistance and climatic factors on fungal diseases in ... -
Juvenile king scallop, Pecten maximus, is potentially tolerant to low levels of ocean acidification when food is unrestricted.
(United States, 2013)The decline in ocean water pH and changes in carbonate saturation states through anthropogenically mediated increases in atmospheric CO2 levels may pose a hazard to marine organisms. This may be particularly acute for ... -
Molecular mechanisms and tissue targets of brominated flame retardants, BDE-47 and TBBPA, in embryo-larval life stages of zebrafish (Danio rerio).
(Elsevier, 2019-04)Brominated flame retardants are known to disrupt thyroid hormone (TH) homeostasis in several vertebrate species, but the molecular mechanisms underlying this process and their effects on TH-sensitive tissues during the ... -
Optimizing the design of a reproduction toxicity test with the pond snail Lymnaea stagnalis.
(2016-11)This paper presents the results from two ring-tests addressing the feasibility, robustness and reproducibility of a reproduction toxicity test with the freshwater gastropod Lymnaea stagnalis (RENILYS strain). Sixteen ... -
Promoting the 3Rs to enhance the OECD fish toxicity testing framework.
(2016-02-09)Fish toxicity testing has been conducted since the 1860's in order to help define safe levels of chemical contaminants in lakes, rivers and coastal waters. The historical emphasis on acute lethality testing of chemicals ... -
Pyrosequencing of Mytilus galloprovincialis cDNAs: tissue-specific expression patterns.
(United States, 2010-01-25)BACKGROUND: Mytilus species are important in marine ecology and in environmental quality assessment, yet their molecular biology is poorly understood. Molecular aspects of their reproduction, hybridisation between species, ... -
The Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment.
(United States, 2017-08-01)In conjunction with the second International Environmental Omics Symposium (iEOS) conference, held at the University of Liverpool (United Kingdom) in September 2014, a workshop was held to bring together experts in ... -
Screening and testing for endocrine disruption in fish-biomarkers as "signposts," not "traffic lights," in risk assessment.
(United States, 2006-04)Biomarkers are currently best used as mechanistic "signposts" rather than as "traffic lights" in the environmental risk assessment of endocrine-disrupting chemicals (EDCs). In field studies, biomarkers of exposure [e.g., ... -
Systems biology meets stress ecology: linking molecular and organismal stress responses in Daphnia magna.
(England, 2008)BACKGROUND: Ibuprofen and other nonsteroidal anti-inflammatory drugs have been designed to interrupt eicosanoid metabolism in mammals, but little is known of how they affect nontarget organisms. Here we report a systems ...
