ORCID
- Ming Li: 0000-0002-2540-1738
Document Type
Article
Abstract
Exosomes, lipid bilayer-enclosed extracellular vesicles, transfer bioactive molecules to mediate intercellular communication and tumour progression. Melanoma differentiation-associated gene 9 (MDA-9/Syntenin) regulates exosome biogenesis, but its role in glioma-derived exosomes remains poorly understood, with prior studies focusing primarily on MDA-9's intracellular functions in glioma cells. Here, we investigate MDA-9-mediated exosomal contributions to glioma pathogenesis. We found that MDA-9 is upregulated in glioma tissues, correlating with poor prognosis in glioma patients. Exosomes from MDA-9-overexpressing glioma cells significantly enhanced recipient glioma cell proliferation and invasion compared to controls. Mechanistically, these exosomes activated the PI3K-AKT pathway, upregulating MMP9 and c-MYC to drive cell proliferation and invasion. These findings reveal a novel role of the exosomal MDA-9–PI3K-AKT–MMP9/c-MYC axis in glioma progression, highlighting MDA-9 as a promising therapeutic target.
DOI Link
Publication Date
2025-10-30
Publication Title
Biochemical and Biophysical Research Communications
Volume
786
ISSN
0006-291X
Acceptance Date
2025-09-25
Deposit Date
2026-10-26
Additional Links
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Zheng, Y., Yu, X., Zhong, Z., & Li, M. (2025) 'MDA-9/Syntenin promotes glioma cell proliferation and invasion via exosome-mediated activation of the PI3K-AKT signaling pathway', Biochemical and Biophysical Research Communications, 786. Available at: 10.1016/j.bbrc.2025.152720
